@Article{Tujakowski2006,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="10",
number="5",
year="2006",
title="Effectiveness and toxicity of Interleukin 2, Interferon \α,and 5-Fluorouracil in patients with Metastatic Renal Cell Cancer",
abstract="  Purpose:  The purpose of this study was to evaluate the potential efficacy and toxicity for the treatment of metastatic renal cell cancer.   Material and methods:    During the first 4 weeks of treatment, patients received s.c. IL-2 (Proleukin) in weeks 1 and 4 (10 MIU/m 2  once daily on days 3-5), in weeks 2 and 3 (5 MIU/m 2  once daily on days 3-5). During weeks 2 and 3, the dosage for IFN-2B (Roferon) was 5 MIU/m 2  on days 1, 3 and 5, in weeks 5-8 (10 MIU/m 2  once daily on days 1, 3 and 5. During weeks 5-8, 5-Fu (5 Fluorouracyl) 1000 mg/m 2  was administered once weekly by a bolus i.v. injection. Eighteen patients entered the study. All had undergone a nephrectomy and had progressive metastatic disease.   Results:    There were one patient with complete responses (CRs) and three with partial responses (PRs) for an objective response rate of 22.2% (95% confidence interval). The CR durations were 20 months for one patient. The patient who remains disease-free had the disease in the lung and kidney. The PR durations ranged from 2 to 9 months. The median survival of the study group is 8.7 months (range 1 to 23 months). The most common toxicities during IL-2/IFN and 5-Fu were fatigue, nausea/vomiting, anorexia, skin rash, injection site inflammation, diarrhea, fever. 12 of 18 patients experienced grade 2/3 granulocytopenia, and four other patients experienced thrombocytopenia. An out-patient treatment system was feasible and positively viewed by the patients.   Conclusions:    In view of a lack of effective therapy methods, the immunochemotherapy applied by the authors on all metastatic renal cell carcinoma patients, may be an optional treatment, with an acceptable level of complications.",
author="Tujakowski, Jerzy
and Roszkowski, Krzysztof
and Ramlau, Rodryg
and Żurawski, Bogdan",
pages="231--235",
url="https://www.termedia.pl/Effectiveness-and-toxicity-of-Interleukin-2-Interferon-945-and-5-Fluorouracil-in-patients-with-Metastatic-Renal-Cell-Cancer,3,6264,1,1.html"
}