@Article{Skowrońska-Jóźwiak2006,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="5",
number="3",
year="2006",
title="Influence of IGF-I and IGFBP-3 on bone mineral density in postmenopausal women",
abstract=" Aim of study:  Serum concentration of insulin-like growth factor-I (IGF-I) decreases with age but the link between IGF-I and postmenopausal osteoporosis remains controversial. IGFBP-3 is IGF-I binding protein, which prolongs the half-life of IGF-I and serves as metabolic reservoir of IGF-I. The goal of this study was to determine the effect of IGF-I and IGFBP-3 on bone mineral density in postmenopausal women.    Materials and methods:  The study included sixty-two (62) postmenopausal women, mean age 69.8\&#177;8.3 years. All the women were examined in order to exclude any other risk factors of osteoporosis.    Results:  Bone mineral density (BMD) was measured in the femoral neck, using dual-energy X-ray absorptiometry (DPX, Lunar, USA). The obtained results were evaluated vs. WHO criteria of osteoporosis. IGF-I and IGFBP-3 were measured by RIA (IGF-I Biosource Europe S.A., Belgium; IGFBP-3 Immunotech, France). Serum concentrations of IGF-I and IGFBP-3 were significantly lower in the group of osteoporotic women and correlated positively with BMD of the femoral neck, respectively (r=0.48, p<0.001 and r=0.43, p<0.001).    Conclusions:  Our study indicates that low concentrations of IGF-I and of its binding protein (IGFBP-3) in postmenopausal women may be responsible for the loss of bone mineral density, thus leading to osteoporosis development.",
author="Skowrońska-Jóźwiak, Elżbieta
and Lewiński, Andrzej",
pages="175--177",
url="https://www.termedia.pl/Influence-of-IGF-I-and-IGFBP-3-on-bone-mineral-density-in-postmenopausal-women,4,6336,1,1.html"
}