@Article{J.W. ten Kate2000,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="4",
number="2",
year="2000",
title="Prognosis after radical esophagectomy for adenocarcinoma of the esophagus according to Laurén classification and c-erbB-2 oncogene overexpression",
abstract="The aim of this study was to investigate the prognostic significance of the Laurén classification and c- erbB -2 oncogene overexpression in adenocarcinoma of the esophagus and/or gastro-esophageal junction (GEJ). Forty-one adenocarcinomas of the esophagus and/or GEJ were reviewed for tumor stage, Laurén classification, and c- erbB -2 by immunohistochemistry. According to the Laurén classification, tumors were classified as intestinal, mixed, or diffuse in 54%, 32%, and 15%, respectively. Diffuse tumors had a significantly worse prognosis than intestinal tumors. The prognostic value of the Laurén classification was independent of stage. C- erbB -2 overexpression was detected in 24% of the tumors and was present exclusively in intestinal tumors and in intestinal-type areas of mixed tumors. Ten of the 30 stage III/IV tumors were c- erbB -2 positive, while none of the 11 stage I/II tumors overexpressed the oncogene product.     Conclusions:   1) the Laurén classification is independent prognostic factor in adenocarcinoma of the esophagus and GEJ,   2) intestinal and diffuse tumors differ oncogenetically,   3) c- erbB -2 overexpression is associated with stage of disease.",
author="J.W. ten Kate, Fiebo
and Johan A. Offerhaus, G.
and Obertop, Hugo
and Jan B. van Lanschot, J.
and W. van Sandick, Johanna
and Polkowski, Wojciech",
pages="68--71",
url="https://www.termedia.pl/Prognosis-after-radical-esophagectomy-for-adenocarcinoma-of-the-esophagus-according-to-Lauren-classification-and-c-erbB-2-oncogene-overexpression,3,659,1,1.html"
}