@Article{Dąbrowski2000,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="4",
number="2",
year="2000",
title="Role of the neoadjuvant therapy in the treatment of advanced carcinoma of the esophagus",
abstract="The aim of this study was to compare microscopically radical resection (R0) rate after surgery alone, preoperative chemotherapy, and preoperative chemo-/radiotherapy.   Between 1992-1997, 101 patients were operated for squamous cell carcinoma of the esophagus. Thirty four patients were treated by surgery alone, in 42 patients surgery followed preoperative chemotherapy with cisplatin (20 mg/m 2 /dobe; days: 1-5 i 17-21 days) and 5-FU (300 mg/m 2 /dobe; for 21 days). In 25 patients concurrently with chemotherapy, radiotherapy was applied in fractions (for 15 days) up to total dose of 3000 cGy. Postoperative mortality and morbidity was 15% and 50%, respectively. In the chemotherapy group, complete response (CR) rate was 4,8%, partial response (PR) was 80,9%, and stabile disease (SD) was observed in 14,3% of patients. In the chemo-/radiotherapy group the CR, PR, and SD rate were 8%, 80%, and 12%, respectively. The R0 resection rates after surgery alone, preoperative chemotherapy and chemo-/radiotherapy were 3%, 26%, and 40%, respectively.   Conclusion: in patients with advanced squamous cell carcinoma of the esophagus, preoperative chemo- and/or radiotherapy improves microscopically radical resection rate, as compared to surgery alone.",
author="Dąbrowski, Andrzej
and Wallner, Grzegorz
and Misiuna, Paweł
and Polkowski, Wojciech",
pages="80--83",
url="https://www.termedia.pl/Role-of-the-neoadjuvant-therapy-in-the-treatment-of-advanced-carcinoma-of-the-esophagus,3,662,1,1.html"
}