@Article{Lewandowski2006,
journal="Archives of Medical Science",
issn="1734-1922",
volume="2",
number="3",
year="2006",
title="Original paperShort-term lifestyle intervention significantly increases fasting adiponectin and induces a decline in serum adiponectin during oral glucose tolerance test, without changes in insulin resistance",
abstract="  Introduction:  Metabolic syndrome is associated with insulin resistance (IR) and low concentrations of adiponectin, an adipocytokine that improves insulin sensitivity and has anti-inflammatory and anti-atherogenic properties. An increase in circulating adiponectin may, therefore, have beneficial effects in terms of reduction of cardiovascular risk. We aimed to establish whether short-term (two-week) lifestyle intervention alters serum concentrations of adiponectin, and whether there are changes in adiponectin during oral glucose tolerance test (OGTT).   Material and methods:  We measured adiponectin levels during 75.0 gram OGTT before and after two weeks of a hospital-based lifestyle modification programme that consisted of hypocaloric diet and moderate exercise in 16 severely obese, non-diabetic subjects (4 males), aged 42.0\&#177;14.18 years, BMI 42.65\&#177;7.82 kg/m2 (mean \&#177;SD). IR indices were assessed before and after intervention.    Results:  Exercise and diet programme resulted in a decline of BMI (to 40.21\&#177;7.14 kg/m2, p<0.001) and fasting glucose (p=0.002), although without significant improvement in IR. There was, however, a significant rise in fasting adiponectin (from 32.1\&#177;13.2 nmol/l to 35.38\&#177;11.04 nmol/l, p=0.008). Furthermore, though initially there was no change in serum adiponectin levels during OGTT, there was a significant decline in serum adiponectin during OGTT at the end of the study (p<0.001).   Conclusions:  A two-week period of lifestyle modification (hypocaloric diet and moderate exercise) increases fasting adiponectin and induces a decline in serum adiponectin during OGTT in severely obese subjects. Favourable changes in serum adiponectin in subjects at high risk of cardiovascular disease are observed after a relatively short period and precede significant changes in insulin resistance.",
author="Lewandowski, Krzysztof C.
and Szosland, Konrad
and Horn, Rudiger
and Brabant, Georg
and Lewiński, Andrzej",
pages="179--184",
url="https://www.termedia.pl/Original-paper-Short-term-lifestyle-intervention-significantly-increases-fasting-adiponectin-and-induces-a-decline-in-serum-adiponectin-during-oral-glucose-tolerance-test-without-changes-in-insulin-re,19,6750,1,1.html"
}