@Article{Rożej2000,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="4",
number="6",
year="2000",
title="Radioprotective effect of natural anthocyanins",
abstract=" Aim : The effect of dye and black-fruit aronia juice on biochemical and morphological parameters in experimental animals exposed to a dose of 1,05 and 4,0 Gy gamma radiation was studied.    Material and methods : The study was performed on 77 Chinchilla rabbits 2,5\–3,2 kg body mass and 76 Balb C mice 18,0\–21,5 g body mass. Blood was collected from rabbits marginal aural vein 48 h prior to irradiation and then 48 h and on 4 th  and 10 th  day after irradiation. In rabbits the leukocytes count and superoxide radical generation stimulated by peripheral blood granulocytes were investigated. In irradiated mice splenocytes chemiluminescence was examined on 3 rd  day.    Results : Statistically significant increase of superoxide radical generation was observed on the 4 th  day after exposure to 1,05 Gy and after 48 h and on the 4 th  day after exposure to a dose of 4 Gy of gamma radiation. Administration of anthocyanin dye inhibits significanthy superoxide radical generation on the 4 th  day after exposure to the radiation dose of 4 Gy. On the 3 rd  day after exposure to 4 Gy of gamma radiation both anthocyanin dye and concentrated juice increase the splenocytes chemiluminescence. Administration of natural anthocyanin dye to irradiated animals improves leukocytes count.    Conclusion :   * after exposure to gamma radiation dose the following was observed in irradiated animals: 1) increase of mean leukocyte count after exposure to a dose 1,05 Gy, 2) decrease of mean leukocyte count after exposure to a dose 4,0 Gy, 3) increase of superoxide radical, 4) decrease of splenocytes chemiluminescence,   * administration of anthocyanin dye to animals exposed to gamma radiation dose of 4 Gy evokes: 1) decrease of superoxide radical generation, 2) increase of splenocytes chemiluminescence,   * administration of anthocyanin dye to animals exposed to gamma radiation dose of 1,05 Gy produces leukocytes count normalisation.",
author="Rożej, Adam
and Małkowski, Bogdan
and Andryskowski, Grzegorz
and Niedworok, Jan
and Grześków, Jerzy
and Tryniszewski, Wiesław
and Maziarz, Zbigniew",
pages="269--272",
url="https://www.termedia.pl/Radioprotective-effect-of-natural-anthocyanins,3,728,1,1.html"
}