@Article{Wlaźlak2006,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="5",
number="6",
year="2006",
title="Expression of metalloproteinases MMP-1 and MMP-9 and tissue inhibitor of metalloproteinases TIMP-1 in cases of endometrial carcinoma and endometrial hyperplasia",
abstract="Excessive extracellular proteolysis attributable to abnormally high matrix metalloproteinases (MMPs) activities, is observed in many invasive neoplasms.    Objective:  The aim of our study was to compare the expression of matrix metalloproteinases MMP-1, MMP-9 and tissue inhibitors of metalloproteinases TIMP-1 in the glandular compartment of endometrial cancer cells and in hyperplastic endometrial cells without atypia.    Material and methods:  Out of the total of 500 specimens from the uterine cavity, obtained from women who have undergone D\&C in the First Institute of Obstetrics and Gynecology Medical University of Lodz, we have selected twenty four: twelve cases of endometrial carcinoma and twelve \– of hyperplasia without atypia.    Results:  MMP-1, MMP-9 oraz TIMP-1 expression was higher in endometrial carcinoma group in comparison to endometrial hyperplasia group. The differences were statistically significant. In most of the cases of endometrial carcinoma TIMP-1 activity was small.    Discussion:  Our results suggest that interaction between MMPs and TIMPs may play important role in invasive processes of endometrial carcinoma.   Key words: endometrium, endometrial cancer, hyperplastic endometrium, matrix metalloproteinases, MMPs, tissue inhibitors of metalloproteinases, TIMPs",
author="Wlaźlak, Edyta
and Surkont, Grzegorz
and Kobos, Józef
and Tyliński, Wiesław
and Stetkiewicz, Tomasz
and Suzin, Jacek",
pages="363--366",
url="https://www.termedia.pl/Expression-of-metalloproteinases-MMP-1-and-MMP-9-and-tissue-inhibitor-of-metalloproteinases-TIMP-1-in-cases-of-endometrial-carcinoma-and-endometrial-hyperplasia,4,7534,1,1.html"
}