@Article{Skrzypulec2006,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="5",
number="6",
year="2006",
title="The influence of sequential transdermal hormone therapy on serum hormone and lipids profile in perimenopausal women",
abstract=" Aim of the study:  The evaluation of the effect of sequential transdermal hormone therapy on serum hormone and lipids profile in perimenopausal women.    Material and methods:  In a six-month (6 treatment periods, 28 days each) randomized study, 75 healthy postmenopausal women aged 48-53(51\±3) were assigned to receive 50 micrograms/day of continuous transdermal estradiol with sequential transdermal norethisterone acetate (NETA) in daily doses of 170 micrograms for in a single transdermal patch.    Results:  Effects on coronary heart disease risk factors, such as reductions in total cholesterol (- 4%; 6\±0.9 mmol/l at baseline an 5.9\±1.0 mmol/l at the end of the study), low-density lipoprotein cholesterol (-4.6%; 3.7\±0.8 mmol/l at baseline and 3.6\±0.9 mmol/l after treatment), triglicerydes (-15.4%; 1.6\±0.9 mmol/l at baseline and 1.8\±1.0 mmol/l after treatment) and significant decrease of high-density lipoprotein cholesterol levels (-17.2%; 1.7\±0.4 mmol/l at baseline and 1.4\±0.3 mmol/l after treatment) were measured in the treatment group. Nonsignificant dicrease within FSH serum levels (65\±33 mIU/ml at baseline and 46\±29 mIU/ml at the end of the study) and nonsignificant rise of  17 beta-estradiol (44\±81 pg/ml at basleine and 189\±236 pg/ml t the end of the study) across treatment were observed.    Conclusions:  Sequential transdermal estrogen/progestogen hormone therapy with estradiol/NETA appears to be effective and safe for serum hormone and lipids profile in perimenopausal women.",
author="Skrzypulec, Violetta
and Rozmus-Warcholińska, Wioleta
and Zdun, Dariusz",
pages="374--381",
url="https://www.termedia.pl/The-influence-of-sequential-transdermal-hormone-therapy-on-serum-hormone-and-lipids-profile-in-perimenopausal-women,4,7536,1,1.html"
}