@Article{Szpecht2007,
journal="Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery",
issn="1731-5530",
volume="4",
number="1",
year="2007",
title="Forum Młodych Chirurgów  The activity of protein C among neonates undergoing surgery for congenital heart defects with cardiopulmonary bypass",
abstract="Introduction: Protein C can influence the postoperative outcome in neonates undergoing correction of congenital heart disease. Aim: The aim of this study was to: 1. analyze the activity of protein C among neonates undergoing CPB, 2. analyze the influence of pre- and perioperative infection risk factors on C protein activity changes, and 3. investigate C protein activities in children with and without postoperative infection.  Material and methods: Eight infants were operated on using CPB in deep and moderate hypothermia (age 97.6 \&#177; 83.8 days). Blood samples were drawn at 6 time points: before general anaesthesia, 5 minutes after the beginning of CPB, 5 minutes before disconnecting from CPB, 15 minutes after administering protamine, and on the second and third postoperative day. The activity of C protein was measured with a CoagChrom 3003 Coagulometr.  Results: The mean baseline C protein activity was below the norm, decreased immediately after the institution of CPB and gradually increased to reach starting values at the end of observation. The changes were significant (p<0.0001). There were no significant statistical differences among children with and without infection risk factors. Similarly, present infection did not influence C protein activity. Conclusions: CPB exacerbates the preoperative deficit of C protein. The subsequent recovery is visible, but C protein activities do not reach normal ranges for the age group.",
author="Szpecht, Dawid
and Wojtalik, Michał
and Mrówczyński, Wojciech
and Poprawski, Grzegorz
and Kempka-Dobra, Ewa",
pages="98--103",
url="https://www.termedia.pl/Forum-Mlodych-Chirurgow-The-activity-of-protein-C-among-neonates-undergoing-surgery-for-congenital-heart-defects-with-cardiopulmonary-bypass,40,7999,1,1.html"
}