@Article{Prochorec-Sobieszek2007,
journal="Reumatologia/Rheumatology",
issn="0034-6233",
volume="45",
number="2",
year="2007",
title="Felty\’s syndrome and T-cell large granular lymphocyte leukaemia  \– similarities and differences",
abstract="Recent studies suggest that Felty\’s syndrome (FS) and T-cell large granular lymphocyte leukaemia (T-LGL) are related disorders that appear to share some pathogenetic mechanisms and clinical features: T-cell large granular lymphocytosis, immune-mediated neutrophil destruction resulting in neutropenia, variable splenomegaly and arthritis. FS is characterized by severe articular and extra-articular manifestations of rheumatoid arthritis (RA), neutropenia and splenomegaly, and in 30% of patients FS is associated with T-cell large granular lymphocytosis. On the other hand, T-LGL presents with monoclonal infiltration of T large granular lymphocytes in the bone marrow and spleen, neutropenia and splenomegaly, and in 25-35% patients it is associated with RA. The article reviews pathogenetic, histopathological, immunogenetic and clinical relations between these two diseases.",
author="Prochorec-Sobieszek, Monika
and Wagner, Teresa
and Maryniak, Renata K.",
pages="85--91",
url="https://www.termedia.pl/Felty-8217-s-syndrome-and-T-cell-large-granular-lymphocyte-leukaemia-8211-similarities-and-differences,18,8101,1,1.html"
}