@Article{Gleń2007,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="24",
number="2",
year="2007",
title="Original article Association of interleukin 13 promoter gene polymorphism with atopic dermatitis",
abstract="Interleukin 13 (IL-13) is a major cytokine involved in IgE synthesis, increased levels of which are observed in the majority of atopic dermatitis (AD) patients. The IL-13 gene has been mapped to the cytokine cluster on chromosome 5q31-33, which has been associated with atopic conditions. Numerous single-nucleotide polymorphisms (SNP) have been identified in the IL-13 gene and have been found to be associated with IgE levels and/or allergic diseases. Recently, polymorphism (C to T exchange) at position -1024 of the promoter region in the IL-13 gene has been described. Some reports indicate that these polymorphisms are associated with allergic asthma, altered regulation of IL-13 production and increased binding of nuclear proteins to this region. The aim of this study was to analyse the association of IL-13 gene polymorphism at position -1024 C/T in patients with atopic dermatitis. In our study we analysed 111 patients with AD and 65 healthy controls. The polymorphism -1024 C/T in the promoter region of the IL-13 gene was typed using ARMS-PCR method. We found that -1024T allele and CT genotypes frequency were significantly higher among patients with atopic dermatitis in comparison with control subjects (55%  vs  31%; OR, 2, 1, p<0.028). In conclusion, our results indicate that presence of -1024 C/T polymorphism of IL-13 gene may predispose to the development of atopic dermatitis in the northern Polish population.",
author="Gleń, Jolanta
and Nedoszytko, Bogusław
and Jasiel-Walikowska, Elżbieta
and Wilkowska, Aleksandra
and Zabłotna, Monika
and Roszkiewicz, Jadwiga",
pages="65--68",
url="https://www.termedia.pl/Original-article-Association-of-interleukin-13-promoter-gene-polymorphism-with-atopic-dermatitis,7,8185,1,1.html"
}