@Article{Sobczuk2007,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="6",
number="4",
year="2007",
title="Comparison of classifications of hyperplastic endometrial lesions  \– World Health Organization and Endometrial Intraepithelial Neoplasia",
abstract="Endometrial intraepithelial neoplasia (EIN) is a precursor to endometrioid endometrial adenocarcinoma characterized by monoclonal growth of mutated cells, a distinctive histopathologic appearance and 45-fold elevated cancer risk. The diagnosis of premalignant endometrial lesions remains non-standardized because the most widely used World Health Organization classification system is a poorly reproducible system, which does not specify objective architectural criteria for each category of hyperplasia and does not correspond to appropriate clinical management (under-treatment, over-treatment of lesions). The new proposed EIN diagnostic schema, based on an integrated morphological, genetic, molecular, objective histomorphometric scale (D-score) and clinical outcome studies, divides endometrial lesions into three categories: benign hyperplasia, endometrial intraepithelial neoplasia, and cancer.",
author="Sobczuk, Anna
and Wrona, Marcin",
pages="199--203",
url="https://www.termedia.pl/Comparison-of-classifications-of-hyperplastic-endometrial-lesions-8211-World-Health-Organization-and-Endometrial-Intraepithelial-Neoplasia,4,8737,1,1.html"
}