@Article{Armstrong2007,
journal="Folia Neuropathologica",
issn="1641-4640",
volume="45",
number="3",
year="2007",
title="Original articleSize frequency distributions of abnormal protein deposits in Alzheimer\’s disease and variant Creutzfeldt-Jakob disease",
abstract="The size frequency distributions of \β-amyloid (A\β) and prion protein (PrP sc ) deposits were studied in Alzheimer\’s disease (AD) and the variant form of Creutzfeldt-Jakob disease (vCJD) respectively. All size distributions were unimodal and positively skewed. A\β deposits reached a greater maximum size and their distributions were significantly less skewed than the PrP sc  deposits. All distributions were approximately log-normal in shape but only the diffuse PrP sc  deposits did not deviate significantly from a log-normal model. There were fewer larger classic A\β deposits than predicted and the florid PrP sc  deposits occupied a more restricted size range than predicted by a log-normal model. Hence, A\β deposits exhibit greater growth than the corresponding PrP sc  deposits. Surface diffusion may be particularly important in determining the growth of the diffuse PrP sc  deposits. In addition, there are factors limiting the maximum size of the A\β and florid PrP sc  deposits.",
author="Armstrong, Richard A.",
pages="108--114",
url="https://www.termedia.pl/Original-article-Size-frequency-distributions-of-abnormal-protein-deposits-in-Alzheimer-8217-s-disease-and-variant-Creutzfeldt-Jakob-disease,20,8763,1,1.html"
}