@Article{Olakowski2007,
journal="Gastroenterology Review/Przegląd Gastroenterologiczny",
issn="1895-5770",
volume="2",
number="4",
year="2007",
title="Review paperThe role of growth factors in pathogenesis of pancreatic cancer. Part I: Epidermal growth factor receptors (EGFR) and heparin-binding EGF-like growth factor (HB-EGF)",
abstract="The epidermal growth factor receptor (EGFR) family consists of a group of transmembrane proteins with an intrinsic tyrosine kinase activity. It consists of 4 members: EGFR/ErbB-1, HER2/ErbB-2, HER3/ErbB-3 and HER4/ErbB-4. Overexpression of EGFR is observed in pancreatic cancer cells in over 40% of specimens from surgically excised tumours. In patients with overexpressed EGFR, liver metastases and local recurrence are more frequently observed. A correlation between expression of EGFR and grading and staging is observed. In experimental studies the overexpression of HER2/neu protein in cells triggers proliferation and is connected with neoplasmatic transformation and metastases. Experimental studies of the usefulness of HER2/neu measurements in clinical practice give inconsistent results. It was shown that overexpression of c-erbB-3 in pancreatic cancer is connected with poor prognosis. Heparin-binding EGF-like growth factor can play a role in auto- and paracrine activation of EGFR, contributing to proliferation of pancreatic cancer cells.",
author="Olakowski, Marek",
pages="170--174",
url="https://www.termedia.pl/Review-paper-The-role-of-growth-factors-in-pathogenesis-of-pancreatic-cancer-Part-I-Epidermal-growth-factor-receptors-EGFR-and-heparin-binding-EGF-like-growth-factor-HB-EGF-,41,8824,1,1.html"
}