@Article{Krakowczyk2007,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="11",
number="6",
year="2007",
title="Epigenetic modification of gene expression in colorectal carcinogenesis",
abstract="Colorectal carcinoma is a common malignancy in both males and females. Current treatment modalities include  surgery, chemotherapy and irradiation  of rectal lesions. Despite these interventions, however, there isconsiderable  variance in treatment success. This has been observed in same-stage tumours treated with standardized surgical and chemotherapeutic schedules. It has  been postulated that these variations arise due to inherent differences in the tumour characteristics, in particular  their molecular profiles. In colorectal  carcinogenesis disturbances different from genetic changes, called epigenetic regulations, are also taken into  consideration. Epigenetics is defined as modifications of the genome, heritable during cell division, that do not involve a change in the DNA sequence. In  humans, the fundamental epigenetic process is DNA methylation and histone modifications. It was demonstrated that certain colorectal cancers originate on the basis of this epigenetic disorder. Hypermethylation was discovered among others in promoters of the following genes \– p16, p14, APC, MGMT and MLH1.",
author="Krakowczyk, Łukasz
and Strzelczyk, Joanna Katarzyna",
pages="289--294",
url="https://www.termedia.pl/Epigenetic-modification-of-gene-expression-in-colorectal-carcinogenesis,3,8844,1,1.html"
}