@Article{Weisinger2007,
journal="Archives of Medical Science",
issn="1734-1922",
volume="3",
number="3",
year="2007",
title="Basic researchEffect of dietary omega-3 fatty acid deficiency  on heart rate variability in hooded rats",
abstract="Introduction: Recent reports in adult humans suggest that heart rate variability is modulated by the concentration of omega-3 polyunsaturated fatty acids (PUFA) contained in blood cell membranes. Material and methods: Hurst analysis of ECG data was conducted on 12 male adult hooded (Long-Evans) rats, representing the 3rd generation to be fed diets that were either deficient in, or supplemented with, omega-3 PUFA. ECG data were obtained from surface electrodes and 4000 beats were analyzed for each animal. Results: Dietary manipulation, despite leading to large changes in tissue omega-3 PUFA levels, did not significantly affect the complexity of heart rate dynamics, with Hurst exponent (H) values of 0.15\±0.02 and 0.12\±0.03, for animals fed omega-3 fatty acid-adequate and -deficient diets, respectively. Mean heart rate was also unaffected by the diets. A power calculation revealed that about one hundred animals per group would have been required to avoid a type II error. Conclusions: According to this model of dietary PUFA manipulation, omega-3 fatty acids are unlikely to exert a large effect on the autonomic functions that control heart rate variability. Prospective studies into the effect of omega-3 fatty acids on HRV should consider the need for large sample size as estimated by the results contained in this report.",
author="Weisinger, Harrison S.
and Salem Jr, Norman
and Makino, Kevin K.
and Hibbeln, Joseph R.
and Sinclair, Andrew J.
and Weisinger, Richard S.
and DePetrillo, Paolo B.",
pages="208--214",
url="https://www.termedia.pl/Basic-research-Effect-of-dietary-omega-3-fatty-acid-deficiency-on-heart-rate-variability-in-hooded-rats,19,9003,1,1.html"
}