@Article{Stella-Hołowiecka2007,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="11",
number="7",
year="2007",
title="Autologous stem cell transplantation (ASCT) as a consolidation  of remission in peripheral T-cell lymphoma (PTCL) \– the preliminary results of the first 11 patients",
abstract="Background: Peripheral T-cell lymphomas show aggressive course and poor outcome. High-dose chemotherapy is thought to improve outcome in these patients, but the role of up-front ASCT is still unclear.  Material and methods: 11 patients  (5 male/6 female); median age at ASCT was 41 years. The CHOP regimen was administered as an induction treatment. The median number of chemotherapy regimens needed to achieve CR or PR was 8 (range 3-20). 7 patients (64%) achieved complete remission before ASCT; 4 showed PR. The conditioning regimen was CBV for 10 patients and 1 patient received BEAM.  Results: The median number of mononuclear cells was 3.5 × 108/kg (range 2.02-6.9); median CD34+ cell dose infused/kg was 6.2 × 106/kg (range 1.1-17.2). Engraftment of neutrophils >0.5 × 109/l was observed at a median of  14 days (range 12-18), engraftment of platelets >50 × 109/l was achieved in  a median of 16 (range 10-30). The  100-day mortality rate was 0%. 4 out  of 11 patients (36%) developed progression/relapse after ASCT after  a median of 7 months (range 4-9). 3 out of 4 patients died in disease progression, 1 patient underwent allogeneic stem cell transplantation. Only 1 out of 7 patients transplanted in CR had an early relapse occurring 4 months after ASCT. With  a median of 20 months (range 6-52) of follow-up 6 patients (55%) remain in CR. The estimated probability of 3-year overall survival (OS) and progression-free survival (PFS) is 60% and 62% respectively.   Conclusions: Up-front ASCT in PTCL is highly effective, but further study with a large post-transplant population are needed to confirm the results.",
author="Stella-Hołowiecka, Beata
and Wieczorkiewicz, Agata
and Helbig, Grzegorz
and Bober, Grażyna
and Wojciechowska, Maria
and Najda, Jacek
and Kachel, Lucja
and Hołowiecki, Jerzy",
pages="376--380",
url="https://www.termedia.pl/Autologous-stem-cell-transplantation-ASCT-as-a-consolidation-of-remission-in-peripheral-T-cell-lymphoma-PTCL-8211-the-preliminary-results-of-the-first-11-patients,3,9047,1,1.html"
}