@Article{Szymanowski2007,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="6",
number="5",
year="2007",
title="Evaluation of the effectiveness of RESAN vaccine in the prophylaxis and treatment of endometriosis  \– an experimental study in an animal model. Part I",
abstract="Endometriosis is a serious social problem. There is no fully effective form of treatment of endometriosis. Immunomodulation might be a chance to improve the results. Objectives: The aim of our study was to evaluate the effectiveness of the RESAN vaccine in the prevention and treatment of endometriosis in an experimental animal study. Materials and methods: A group of 58 sexually mature female rats was divided into three smaller groups. During the first step of the experiment RESAN vaccine was injected in group I of rats (n=24). Three months later during the 2nd step of the examination endometriosis was implanted in groups I and II (n=24). Group III (n=10) was a control group where sham operations were performed. Three months later endometrial implants were removed and examined histologically. Meanwhile RESAN vaccine was injected as a treatment in group II (step 3). Three months later an excision of the suspected foci was performed with histological examination of the tissue samples (step 4).  Results: During step 3, the endometriosis was histologically diagnosed in 1 rat from group I and in 16 from group II. Adhesions near the endometrial implant were found in 3 and 14 rats from groups I and II, respectively. There were no endometriotic foci in all groups during the 4th step of the examination.  Conclusions: 1. RESAN vaccine is an effective form of endometriosis prevention in a rat model.  2. Immunotherapy connected with surgical treatment is an effective form of treatment in an animal model  of endometriosis.",
author="Szymanowski, Krzysztof
and Chmaj-Wierzchowska, Karolina
and Niepsuj, Joanna
and Yanchanka, Andrey
and Florek, Ewa
and Barlik, Magdalena
and Opala, Tomasz",
pages="283--288",
url="https://www.termedia.pl/Evaluation-of-the-effectiveness-of-RESAN-vaccine-in-the-prophylaxis-and-treatment-of-endometriosis-8211-an-experimental-study-in-an-animal-model-Part-I,4,9168,1,1.html"
}