@Article{Sobczuk2007,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="6",
number="6",
year="2007",
title="MMAC/PTEN gene expression in endometrial cancer \– RT-PCR studies",
abstract="Mutations in the  MMAC/PTEN  (phosphatase and tensin homologue deleted on chromosome 10) gene are documented in cancers of the breast, prostate, ovary, colon, melanoma, glioblastoma, lymphoma and endometrium.  In the present work  MMAC/PTEN  gene expression in women with endometrial adenocarcinoma (n=70) in RNA samples obtained from cancer tissue were investigated. Control DNA was obtained from 68 normal endometrial tissue samples. The  MMAC/PTEN  expression was determined by RT-PCR analysis. Expression of the  MMAC/PTEN  gene in endometrial adenocarcinoma cases was significantly reduced compared to the expression in the normal samples (p<0.05). Furthermore a significant difference (p<0.05) was observed between the expression of  MMAC/PTEN  in stage III  versus  lower stages of endometrial cancer. The results support the hypothesis that  MMAC/PTEN  gene expression may be associated with the incidence of endometrial cancer.",
author="Sobczuk, Anna
and Romanowicz-Makowska, Hanna
and Pertyński, Tomasz",
pages="344--346",
url="https://www.termedia.pl/-MMAC-PTEN-gene-expression-in-endometrial-cancer-8211-RT-PCR-studies,4,9496,1,1.html"
}