@Article{Adamczyk2007,
journal="Folia Neuropathologica",
issn="1641-4640",
volume="45",
number="4",
year="2007",
title="Alpha-synuclein decreases arachidonic acid incorporation into rat striatal synaptoneurosomes",
abstract="In the present study we investigated the role of alpha-synuclein (ASN) and its fragment NAC in arachidonic acid (AA) turnover in the rat brain. Our data indicated that ASN (10 \µM) inhibited [3H]AA incorporation into phosphatidylethanolamine (PE), phosphatidylcholine (PC) and phosphatidylserine (PS) together with phosphatidic acid (PA) by 13%, 27% and 38%, respectively. NAC (10 \µM) reduced [3H]AA incorporation into PC and PA + PS by 17% and 34%, respectively. Because ASN and NAC lower the level of AA-CoA we suggest that inhibition of AA-CoA synthase is responsible for disturbed [3H]AA incorporation. In conclusion, ASN and NAC modulate phospholipid compositions in plasma membranes and affect synaptic endings function.",
author="Adamczyk, Agata
and Kacprzak, Maria
and Kaźmierczak, Anna",
pages="230--235",
url="https://www.termedia.pl/Alpha-synuclein-decreases-arachidonic-acid-incorporation-into-rat-striatal-synaptoneurosomes,20,9577,1,1.html"
}