@Article{Niebroj-Dobosz2007,
journal="Folia Neuropathologica",
issn="1641-4640",
volume="45",
number="4",
year="2007",
title="Myelin composition of spinal cord in a model of amyotrophic lateral sclerosis (ALS) in SOD1G93A transgenic rats",
abstract="We present the results of biochemical and electron microscopic (EM) examinations of the spinal cord myelin from SOD1G93A transgenic Sprague Dawley rats in the early and late symptom-free period of the disease (60 and 93 days of life) and after four-leg paralysis has occurred (120 days of life). Biochemical and ultrastructural changes of myelin started already in the symptom-free period and become most pronounced in the paralyzed animals. Biochemical examinations indicated a decrease of lipids, phospholipids, cholesterol and cerebrosides. The pattern of particular phospholipids was in the normal range. A progressive decrease of the percentages of proteolipid, DM-20  and Wolfgram proteins was evident. Myelin basic proteins I and II were less affected. In EM, massive myelin disorganization was observed.",
author="Niebroj-Dobosz, Irena
and Rafałowska, Janina
and Fidziańska, Anna
and Gadamski, Roman
and Grieb, Paweł",
pages="236--241",
url="https://www.termedia.pl/Myelin-composition-of-spinal-cord-in-a-model-of-amyotrophic-lateral-sclerosis-ALS-in-SOD1-G93A-transgenic-rats,20,9578,1,1.html"
}