@Article{Romanowicz-Makowska2008,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="7",
number="1",
year="2008",
title="The significance of G/C polymorphism of the RAD51 gene in postmenopausal women with breast cancer",
abstract="Objective: Breast cancer is one of the major killers worldwide. In this study the G/C polymorphism of the RAD51 gene in women with breast cancer was investigated.  Material and methods: 100 breast cancer women provided blood for mutation analysis. Blood samples from age-matched healthy individuals (n=106) served as controls. The G/C polymorphism was determined by PCR-RFLP methods.  Results: The distribution of genotypes of the G/C polymorphism of RAD51 in both controls and patients did not differ significantly (p>0.05) from those predicted by the Hardy-Weinberg distribution. There were no significant differences in the genotype distributions and allele frequencies between node-positive and node-negative patients.  Conclusion: Our study implies that it is possible that the G/C polymorphism of the RAD51 gene may not be directly involved in the development and/or progression of breast cancer, but further research, conducted on  a larger population, is needed to clarify this point.",
author="Romanowicz-Makowska, Hanna
and Smolarz, Beata
and Sobczuk, Anna
and Pertyński, Tomasz",
pages="38--41",
url="https://www.termedia.pl/The-significance-of-G-C-polymorphism-of-the-RAD51-gene-in-postmenopausal-women-with-breast-cancer,4,9931,1,1.html"
}