%0 Journal Article %J Contemporary Oncology/Współczesna Onkologia %@ 1428-2526 %V 14 %N 2 %D 2010 %F Synowiec2010 %T Status of the BRCA1 gene and incidence of hereditary ovarian cancer %X Ovarian cancer is the leading cause of mortality in women with gynaecological cancers. Cytoreductive surgery has been considered as a mainstay in manage­ment of ovarian cancer for a long time. Further chemotherapy, based on platinum compounds and taxanes given in an adjuvant setting, allows 5-year survival to be achieved in 10-30% of ovarian cancer patients. Among these cases, it is thought that 5-10% of patients have familial or hereditary disease in which mutations within BRCA genes are the main culprits of 80-90% of ovarian cancer sufferers. The risk of ovarian cancer development in carriers of a mutated BRCA1 gene is 16-60%, which underlines the great need for a precise tool in the form of molecular tests. Now it is time for development of a direct-to-consumer (DTC) strategy that offers commercially available molecular tests with wide utility. %A Synowiec, Agnieszka %A Wcisło, Gabriel %A Bodnar, Lubomir %A Szarlej-Wcisło, Katarzyna %A Cieślak, Agata %A Sielużycka, Joanna %A Szczylik, Cezary %P 72-78 %9 journal article %R 10.5114/wo.2010.13915 %U http://dx.doi.org/10.5114/wo.2010.13915