%0 Journal Article %J Videosurgery and Other Miniinvasive Techniques %@ 1895-4588 %V 8 %N 2 %D 2013 %F Grueneberger2013 %T Long segment ileal transposition leads to early amelioration of glucose control in the diabetic obese Zucker rat %X Introduction : Fast delivery of food to the terminal ileum is thought to be pathophysiologically responsible for type 2 diabetes remission after obesity surgery. Imitating this effect, ileal transposition (IT) is designed as initiating diabetes remission for non-obese patients. Aim: To date, it is not clear which length of the transposed segment achieves the best glucose lowering results. As previous rodent data mostly rely on a 10 cm IT, the current study evaluated a long segment IT (20 cm) in the diabetic obese Zucker rat. Material and methods : Twenty male diabetic obese Zucker rats (Crl:ZUC-Leprfa) were randomly assigned to undergo either a long segment (20 cm; ~ 50% of ileum) IT or sham surgery. Glucose control was determined by an oral glucose tolerance test (OGTT) on day –7, 0, 14 and 20. Analysis of the incretin hormones glucagon-like peptide 1 (GLP-1), peptide YY (PYY) and insulin was included in the first and third OGTT. Results : Ileal transposition animals showed an early improvement of glucose control after 14 days (area under the curve: IT vs. baseline 314.7 ±229.0 mmol/l × min vs. 564.6 ±268.5 mmol/l × min; p < 0.05). Compared to sham animals, glucose-stimulated GLP-1 and PYY levels were raised (5.75 ±3.73 pmol/l vs. 18.52 ±14.22 pmol/l, p < 0.05; 129.7 ±64.62 pmol/l vs. 164.0 ±62.26 pmol/l, p < 0.05). Body weight gain from postoperative day 5 was greater for sham animals (50.22 ±20.93 γ vs. 16.4 ±25.93 g; p < 0.01). Conclusions : Long segment IT shows a rapid rise in GLP-1 and PYY levels, thus leading to early amelioration of glucose control. %A Grueneberger, Jodok Matthias %A Fritz, Tobias %A Zhou, Cheng %A Meyer, Sebastian %A Karcz-Socha, Iwona %A Sawczyn, Tomasz %A Stygar, Dominica %A Goos, Matthias %A Hopt, Ulrich Theodor %A Küsters, Simon %P 130-138 %9 journal article %R 10.5114/wiitm.2011.32925 %U http://dx.doi.org/10.5114/wiitm.2011.32925