%0 Journal Article %J Contemporary Oncology/Współczesna Onkologia %@ 1428-2526 %D 2018 %F Whiteside2018 %T The emerging role of plasma exosomes in diagnosis, prognosis and therapies of patients with cancer %X Exosomes, small (30-150nm) extracellular vesicles of endocytic origin, are present in all body fluids of cancer patients. Tumor-derived exosomes, TEX, emerge as potentially promising non-invasive biomarkers of tumor progression and of immune cell dysfunction in cancer. Exosomes isolated from plasma by size exclusion chromatography can be fractionated into TEX and non-TEX by immune capture on beads. Profiling of molecular and genetic contents of TEX shows that levels if immunosuppressive proteins, such as PD-L1, carried by TEX associate with disease progression. The data suggest that TEX have a to serve as tumor surrogates, while immune cell-derived exosomes might serve as biomarkers of immune dysfunction in cancer. %A Whiteside, Theresa L. %P 38-40 %9 journal article %R 10.5114/wo.2018.73882 %U http://dx.doi.org/10.5114/wo.2018.73882