%0 Journal Article %J Reumatologia/Rheumatology %@ 0034-6233 %V 43 %N 2 %D 2005 %F 3216 %T Influence of tumor necrosis factor-αgen polymorphisms on susceptibility to, and severity of rheumatoid arthritis %X Review of clinical data of European, Taiwan and Chilean population based on publications was done. Until now a total of nine single nucleotide polymorphisms (SNP) were identified. One of which is located in the first introne at position +489, one at position +70 in the 5’ untranslated region (UTR) and seven in the 5’ regulatory region, a region involved in the regulation of TNF gene transcription at position -163G/A, -238G/A, -244G/A, -308G/A, -376G/A, -857C/T, -863C/A. The polymorphisms at position -238, -376, -308 and +489 were studied with particular attention. The polymorphisms at position -238 and -376 were found to be in strong linkage disequilibrium. In presented data no associations between the TNF-α gen polymorphisms and susceptibility to, or severity of, RA could be demonstrated in tested populations. %P 75-79 %9 journal article %U https://www.termedia.pl/Influence-of-tumor-necrosis-factor-945-gen-polymorphisms-on-susceptibility-to-and-severity-of-rheumatoid-arthritis,18,3216,1,1.html