%0 Journal Article %J Archives of Medical Science %@ 1734-1922 %D 2019 %F Karwacki2019 %T Coordinated medical care for children with neurofibromatosis type 1 and related RASopathies in Poland %X Coordinated medical care offered in Poland for patients suffering from neurofibromatosis type 1 and related RASopathies combines complex multispecialty consultation with permanent supervision and the patient’s oriented longitudinal care. Neurofibromatosis type 1 is one of the most common single gene disorders in the global population, observed in 1 out of 2500–3000 live births. It is a primary neoplasia disease with 100% penetration of the gene mutation but remarkable age-dependent onset of different disease signs and symptoms, outstanding clinical heterogeneity between patients even in one family and lack of genotype-phenotype correlation, a high rate of spontaneous mutation exceeding 50%, and multiple comorbidities among which increased risk of malignancy is the most important. Medical practice proved that not only patient-oriented complex but also coordinated care provided in centers of competence is indispensable for patients and the families and provides a sense of medical security to them in conjunction with public health costs rationalization. %A Karwacki, Marek W. %A Wysocki, Mariusz %A Perek-Polnik, Marta %A Jatczak-Gaca, Agnieszka %9 journal article %R 10.5114/aoms.2019.85143 %U http://dx.doi.org/10.5114/aoms.2019.85143