%0 Journal Article %J Alergologia Polska - Polish Journal of Allergology %@ 2353-3854 %V 8 %N 1 %D 2021 %F Waszczykowska2021 %T Asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome and the risk of severe COVID-19 %X Asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome (ACOS) significantly affect the patient’s respiratory system, which requires individualised treatment and professional control. During the SARS-CoV-2 pandemic, all respiratory diseases were taken into consideration as risk factors for severe COVID-19. ACE2 and TMPRSS2 genes, which are crucial for SARS-CoV-2 to enter the host cell, have different expression in the occurrence of asthma or COPD. Also, comparing the severity and mortality of patients with coexistence of asthma or COPD and COVID-19, only COPD patients had worse outcomes of COVID-19, and their mortality was significantly higher. Although ACOS is also a potential risk factor for hospitalisation and mortality in COVID-19 patients, the condition still requires further studies. This overview presents the current state of knowledge on the relationship between the diseases mentioned above and COVID-19. %A Waszczykowska, Klaudia %A Węgierska, Marta %A Drygała, Roxana %A Pawliczak, Rafał %P 21-30 %9 journal article %R 10.5114/pja.2021.104655 %U http://dx.doi.org/10.5114/pja.2021.104655