%0 Journal Article %J Folia Neuropathologica %@ 1641-4640 %V 60 %N 3 %D 2022 %F Acewicz2022 %T Incidence and morphology of secondary TDP-43 proteinopathies: Part 1 %X Transactive response DNA binding protein of 43 kDa (TDP-43) is considered to play an essential role in the pathogenesis of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Growing body of evidence indicate that pathological TDP-43 inclusions frequently occur in the context of other distinctive hallmark pathologies, referred to as secondary TDP-43 proteinopathies. Comorbid TDP-43 pathology is well-documented in several neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, multiple system atrophy, or progressive supranuclear palsy. It may also appear as a consequence of less obvious disease etiologies, i.e. post-traumatic (chronic traumatic encephalopathy), neoplastic (pilocytic astrocytoma), or post-infectious (post-encephalitic parkinsonism). The aim of the present review was to evaluate the incidence, morphology, and role of TDP-43 pathology in the secondary TDP-43 proteinopathies. This article (Part 1) discussed TDP-43 pathology in more common neurodegenerative diseases, including Alzheimer’s disease, Lewy body disease, Huntington’s disease, multiple system atrophy, corticobasal degeneration, and progressive supranuclear palsy. A follow-up article (Part 2) will describe abnormal TDP-43 changes in rare neurodegenerative diseases or neurological diseases with nondegenerative etiology. %A Acewicz, Albert %A Stępień, Tomasz %A Felczak, Paulina %A Tarka, Sylwia %A Wierzba-Bobrowicz, Teresa %P 267-276 %9 journal article %R 10.5114/fn.2022.120314 %U http://dx.doi.org/10.5114/fn.2022.120314