TY - JOUR JO - Central European Journal of Immunology SN - 1426-3912 VL - 28 IS - 1 PY - 2003 ID - Głowacka2003 TI - Experimental immunology Diminished reactive oxygen intermediates (ROI) production, decreased the T suppressor cells number and increased cytokine production constitute outline of the lichen sclerosus pathogenesis AB - Abstract The involution of lichen sclerosus (LS) affected tissues may be the effect of suppression exerted by T lymphocytes which are involved in the pathogenesis of this disease. Inflammatory infiltrates in the affected regions of the skin consist mainly of CD3+ lymphocytes consist with diminished number of CD3+/CD26+ subsets. We revealed the diminished ROI production by peripheral blood, granulocytes after receptor dependent and receptor independent stimulation. The diminished number both of CD3+/CD25+ and CD3+/CD26+ in peripheral blood baseline increase of IL-12 and stimulated increase of IL-2, IL-5, IL-10 and TNF-α production by peripheral blood lymphocytes were also noted. We postulate that immunereactions are involved in LS pathogenesis. Key wo Abstract The involution of lichen sclerosus (LS) affected tissues may be the effect of suppression exerted by T lymphocytes which are involved in the pathogenesis of this disease. Inflammatory infiltrates in the affected regions of the skin consist mainly of CD3+ lymphocytes consist with diminished number of CD3+/CD26+ subsets. We revealed the diminished ROI production by peripheral blood, granulocytes after receptor dependent and receptor independent stimulation. The diminished number both of CD3+/CD25+ and CD3+/CD26+ in peripheral blood baseline increase of IL-12 and stimulated increase of IL-2, IL-5, IL-10 and TNF-α production by peripheral blood lymphocytes were also noted. We postulate that immunereactions are involved in LS pathogenesis. AU - Głowacka, Ewa AU - Rotsztejn, Helena AU - Tchórzewski, Henryk AU - Banasik, Małgorzata AU - Lewkowicz, Przemysław SP - 1 EP - 5 DA - 2003 UR - https://www.termedia.pl/Experimental-immunology-Diminished-reactive-oxygen-intermediates-ROI-production-decreased-the-T-suppressor-cells-number-and-increased-cytokine-production-constitute-outline-of-the-lichen-sclerosus-pat,10,1478,1,1.html ER -