TY - JOUR JO - Gastroenterology Review/Przegląd Gastroenterologiczny SN - 1895-5770 VL - 5 IS - 3 PY - 2010 ID - Parzęcka2010 TI - Influence of Helicobacter pylori genetic type on gastroesophageal acid reflux disease in children and teenagers AB - Introduction: The role of Helicobacter pylori (H. pylori) infection in pathogenesis of gastroesophageal reflux disease (GERD) remains controversial. It seems that the genotype of H. pylori influences that dependence. Aim: To assess the significance of H. pylori genotype in gastroesophageal reflux (GER) in children and teenagers. Material and methods: Hundred and one children in whom endoscopy of the upper part of the gastrointestinal tract was performed and H. pylori infection was demonstrated in histopathological and/or urease test and urea breath test. Helicobacter pylori identification was performed using the PCR method to determine the genetic type of CagA and VacA. Triple-drug eradication therapy was introduced. pH-metric examination was performed before and after treatment. Results: Infection with type I strain was found in 32.7% of patients, type II in 67.3%. Concerning the group of patients infected with type I H. pylori, GER was found in 57.6% of patients, while 45.6% infected with type II H. pylori suffered from GER. It was induced de novo in 15% of patients in the group of patients infected with type I and in 15% of cases was removed after eradication. Change concerning GER intensity degree did not occur in 70% of patients. Gastroesophageal reflux was induced de novo in the group of patients infected with type II H. pylori in 12.8% of cases and GER was removed after eradication in 12.8%. Change concerning GER intensity degree did not occur in 74.4% of patients. The pH-metry result after treatment was non-diagnostic in 5 patients. These differences were not statistically significant. Conclusions: Genetic type of H. pylori did not influence gastroesophageal reflux occurrence or change of gastro­esophageal reflux intensity degree after eradication. AU - Parzęcka, Monika AU - Szaflarska-Popławska, Anna AU - Mierzwa, Grażyna AU - Gorzkiewicz, Marta AU - Łuczak, Sylwia AU - Grzybowski, Tomasz AU - Czerwionka-Szaflarska, Mieczysława SP - 151 EP - 156 DA - 2010 DO - 10.5114/pg.2010.14140 UR - http://dx.doi.org/10.5114/pg.2010.14140 ER -