TY - JOUR JO - Archives of Medical Science SN - 1734-1922 VL - 8 IS - 2 PY - 2012 ID - Bączyk2012 TI - Clinical researchMultifactorial analysis of risk factors for reduced bone mineral density among postmenopausal women AB - Introduction : The study aimed to determine the risk factors for reduced bone mineral density (BMD) among postmenopausal women. Material and methods: Two hundred and fifty-three postmenopausal women were included to the study. The study group consisted of 85 women with osteoporosis (mean age: 59.9 years) and 168 with osteopenia (mean age: 57.8 years). Patients were assigned to groups according to their BMD measured in the lumbar spine, hip and femoral neck by dual X-ray absorptiometry. Bone formation was assessed by measuring serum osteocalcin and bone resorption by measuring serum C-terminal type I α-collagen chain telopeptide. Results : Multiple regression analysis for lumbar spine showed association of age (p = 0.001), parental history of fracture (p = 0.05), use of hormone replacement therapy (p = 0.034), bisphosphonates therapy (p < 0.001), calcium and vitamin D supplements therapy (p = 0.001), oestradiol level (p = 0.007) and body mass index (p < 0.001). Multiple regression analysis for femoral neck and hip total showed association of age (p = 0.001), parental history of fracture (p = 0.049), use of bisphosphonates (p < 0.03)) use of calcium and vitamin D supplements (p = 0.039), oestradiol level (p = 0.047). All the variables together explain 40.4% of variance in BMD for the lumbar spine and 25.6% of variance in BMD for femoral neck and hip total. Conclusions : The present study demonstrated correlations between the variables and BMD, which are known and widely described in the literature. Osteoporosis and osteopenia in Polish subjects appear to be associated with several known risk factors that are well described in the literature. AU - Bączyk, Grażyna AU - Opala, Tomasz AU - Kleka, Paweł AU - Chuchracki, Marek SP - 332 EP - 341 DA - 2012 DO - 10.5114/aoms.2012.28562 UR - http://dx.doi.org/10.5114/aoms.2012.28562 ER -