TY - JOUR JO - Contemporary Oncology/Współczesna Onkologia SN - 1428-2526 VL - 16 IS - 5 PY - 2012 ID - Karbownik2012 TI - The physical and chemical stability of cisplatin (Teva) in concentrate and diluted in sodium chloride 0.9% AB - Aim of the study : The subject of study was the stability of cisplatin in concentrate in glass vials and diluted in polyethylene (PE) bags stored at 15–25°C for up to 30 days. Material and methods : Original vials of cisplatin injection (1 mg/ml, Teva) were stored at room temperature and subjected to re-piercing after 1, 2, 3, 7, 14, 21, 28 and 30 days following the initial piercing. Cisplatin infusions at nominal concentrations of 0.1 mg/ml were prepared in 0.9% sodium chloride (1000 ml) in PE bags. Chemical stability was measured by means of a stability-indicating high-performance liquid chromatography (HPLC) assay. Physical stability was assessed by visual inspection in normal light. Results : The concentration of cisplatin at each sampling time in the analysed solutions remained within 92.0–100.7% of initial concentration, regardless of the container. No changes in colour or turbidity were observed in any of the vials or prepared solutions. Conclusions : Cisplatin, both undiluted in glass containers and diluted with NaCl 0.9% in PE bags, remains stable (< 10% degradation) for at least 30 days at room temperature when protected from light. AU - Karbownik, Agnieszka AU - Szałek, Edyta AU - Urjasz, Hanna AU - Głęboka, Aleksandra AU - Mierzwa, Emilia AU - Grześkowiak, Edmund SP - 435 EP - 439 DA - 2012 DO - 10.5114/wo.2012.31775 UR - http://dx.doi.org/10.5114/wo.2012.31775 ER -