TY - JOUR JO - Przegląd Kardiodiabetologiczny/Cardio-Diabetological Review SN - 1896-9666 PY - 2012 ID - Siewko2012 TI - Original paperInsulin resistance and fasting plasma glucose in first degree relatives of the patients with type 1 diabetes AB - Introduction : By the long time of prediabetes period we don’t observe disturbances of carbohydrate metabolism, which lead to the manifestation of the loss of 80-90% of the β cell mass. Aim : Evaluation of the secretory function of β cells as well as insulin resistance in relation to fasting plasma glucose (FPG). Material and methods : The study was conducted in 90 I° relatives, which were divided on: “high-normal” FPG group ( 88 mg/dl) and “low-normal” FPG group (< 88/mg/dl). The FPG was determined using enzymatic method. HOMAIR and HOMA%B indices were calculated using computer calculator. Results: In 48.9% of patients, a FPG  88 mg/dl was stated. Positive correlations between “high-normal” FPG and body mass index (r = 0.491, p < 0.0001) and between “high-normal” FPG and HOMAIR (r = 0.186, p < 0.002) were observed. A negative correlation between “high-normal” FPG and HOMA%B (r = –0.437, p < 0.0001) were also observed. Conclusions : The patients with the “high-normal” FPG characterize a higher body mass index, insulin resistance and a higher decrease of β-cell function as compared to a “low-normal” FPG group. AU - Siewko, Katarzyna AU - Popławska-Kita, Anna AU - Maciulewski, Rafał AU - Zielińska, Anna AU - Nikołajuk, Agnieszka AU - Górska, Maria AU - Szelachowska, Małgorzata SP - 99 EP - 102 DA - 2012 UR - https://www.termedia.pl/Original-paper-Insulin-resistance-and-fasting-plasma-glucose-in-first-degree-relatives-of-the-patients-with-type-1-diabetes,47,19869,1,1.html ER -