TY - JOUR JO - BioTechnologia SN - 0860-7796 VL - 94 IS - 1 PY - 2013 ID - Budzko2013 TI - Activation-induced cytidine deaminase (AID): single activity – pleiotropic effect AB - Activation-induced cytidine deaminase (AID) plays an essential role in the generation of a highly competent repertoire of antibodies by participating in class switch recombination (CSR) and somatic hypermutation (SHM). After B cell stimulation by antigens, AID initiates SHM and CSR by deamination of cytidine to uridine in the variable and constant regions of Ig genes. An adverse effect of AID’s ability to directly modify genome sequences is its mutagenic potential. AID has been shown to occasionally target non-Ig genes and its abnormal expression is strongly associated with tumorigenesis. Aberrant AID expression can also be triggered by some oncogenic pathogens, such as Helicobacter pylori and several viruses. The latest reports show that also under physiological conditions AID might act beyond the immune system. Data exist suggesting that AID can play a role in the process of active genome demethylation – the heart of epigenetic gene activation and reprogramming. Moreover, it has been shown that abnormal genome demethylation mediated by AID might be associated with human colon cancers. The potential role of AID in the active demethylation process is still controversial, but the hypothesis that aberrant AID expression may cause cancerogenesis by changing genome methylation patterns appears highly attractive. As a unique human enzyme able to induce both genetic and epigenetic alterations under physiological and pathological conditions, AID could be a promising and versatile drug target. In this review we present the current state of knowledge on this topic and the controversies surrounding the pleiotropic effect of AID function. AU - Budzko, Lucyna AU - Jackowiak, Paulina AU - Figlerowicz, Marek SP - 15 EP - 21 DA - 2013 DO - 10.5114/bta.2013.46428 UR - http://dx.doi.org/10.5114/bta.2013.46428 ER -