TY - JOUR JO - Reumatologia/Rheumatology SN - 0034-6233 VL - 52 IS - 5 PY - 2014 ID - Dytfeld2014 TI - Bone and adipose tissue – more and more interdependence AB - In bone marrow, osteoblasts and adipocytes originate from common progenitor cells – mesenchymal stem cells (MSCs). The further cell differentiation towards one of the two lines, depending on numerous factors, might have an impact on pathologies of bone in further life. Evidence from experimental and clinical studies indicates multiple reciprocal links between skeleton and adipose tissue. Numerous adipocyte products – leptin, adiponectin, etc. – directly or indirectly affect bone formation and resorption, which take place constantly. This knowledge verifies our views on obesity, osteoporosis and fragility fractures. We also know that bone remodeling, a process that requires energy, is heavily dependent on insulin; moreover, bone is a source of osteocalcin, a hormone whose role goes far beyond determining the level of bone turnover. The endocrine role of the skeleton becomes a reality. AU - Dytfeld, Joanna SP - 305 EP - 310 DA - 2014 DO - 10.5114/reum.2014.46668 UR - http://dx.doi.org/10.5114/reum.2014.46668 ER -