TY - JOUR JO - Contemporary Oncology/Współczesna Onkologia SN - 1428-2526 PY - 2015 ID - Kwiatkowska-Borowczyk2015 TI - ReviewImmunotargeting of cancer stem cells AB - Cancer stem cells (CSCs) represent a distinctive population of tumour cells that control tumour initiation, progression, and maintenance. Their influence is great enough to risk the statement that successful therapeutic strategy must target CSCs in order to eradicate the disease. Because cancer stem cells are highly resistant to chemo- and radiotherapy, new tools to fight against cancer have to be developed. Expression of antigens such as ALDH, CD44, EpCAM, or CD133, which distinguish CSCs from normal cells, together with CSC immunogenicity and relatively low toxicity of immunotherapies, makes immune targeting of CSCs a promising approach for cancer treatment. This review will present immunotherapeutic approaches using dendritic cells, T cells, pluripotent stem cells, and monoclonal antibodies to target and eliminate CSCs. AU - Kwiatkowska-Borowczyk, Eliza P. AU - Gąbka-Buszek, Agnieszka AU - Jankowski, Jakub AU - Mackiewicz, Andrzej SP - 52 EP - 59 DA - 2015 DO - 10.5114/wo.2014.47129 UR - http://dx.doi.org/10.5114/wo.2014.47129 ER -