TY - JOUR JO - Contemporary Oncology/Współczesna Onkologia SN - 1428-2526 PY - 2015 ID - Gładych2015 TI - ReviewEpigenetic mechanisms of induced pluripotency AB - Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) requires profound alterations in the epigenetic landscape. During reprogramming, a change in chromatin structure resets the gene expression and stabilises self-renewal. Reprogramming is a highly inefficient process, in part due to multiple epigenetic barriers. Although many epigenetic factors have already been shown to affect self-renewal and pluripotency in embryonic stem cells (ESCs), only a few of them have been examined in the context of dedifferentiation. In order to improve current protocols of iPSCs generation, it is essential to identify epigenetic drivers and blockages of somatic cell reprogramming. AU - Gładych, Marta AU - Andrzejewska, Anastazja AU - Oleksiewicz, Urszula AU - Estécio, Marcos R.H. SP - 30 EP - 38 DA - 2015 DO - 10.5114/wo.2014.47135 UR - http://dx.doi.org/10.5114/wo.2014.47135 ER -