TY - JOUR JO - Polish Journal of Pathology SN - 1233-9687 VL - 65 IS - 4 PY - 2014 ID - Poletajew2014 TI - Original paperComparison of pathological staging and grading of urothelial bladder carcinoma in post-transurethral resection and post-radical cystectomy specimens AB - Staging and grading of bladder cancer have a substantial impact on patients’ prognosis. However, due to the relatively low quality and quantity of specimens from transurethral resection (TUR), initial histopathological examination may not be fully reliable. The aim of this study was to assess the repeatability of staging and grading in post-TUR and post-radical cystectomy (RC) specimens. Staging and grading in TUR and RC specimens were compared in a group of 181 consecutive patients. All microscopic examinations were performed by dedicated uropathologists. Median time from TUR to RC was 45 days. Additionally, an attempt to identify potential clinical variables influencing the risk of discrepancies was made. In post-RC specimens, the disease was down-staged in 13.8% and up-staged in 54.6% of patients (K = –0.03, p < 0.02). Muscle-invasive bladder cancer was diagnosed in 67.6% of patients initially staged as T1. Cancer was down-graded in 10.3% and up-graded in 17.9% of patients (K = 0.44, p < 0.02). Early onset of disease, female sex and time interval from transurethral resection of bladder tumor (TURBT) to RC had no effect on incidence of discrepancies. Pathological post-TUR examination is not predictive for the final stage of cancer. The incidence of under- or overgrading of bladder cancer is significant, and efforts should be made to reduce it. AU - Poletajew, Sławomir AU - Fus, Łukasz AU - Walędziak, Maciej AU - Pomada, Paweł AU - Ciechańska, Joanna AU - Wasiutyński, Aleksander AU - Radziszewski, Piotr AU - Górnicka, Barbara SP - 305 EP - 312 DA - 2014 DO - 10.5114/pjp.2014.48192 UR - http://dx.doi.org/10.5114/pjp.2014.48192 ER -