TY - JOUR JO - Archives of Medical Science SN - 1734-1922 VL - 13 IS - 6 PY - 2017 ID - Tastekin2017 TI - Survivin expression, HPV positivity and microvessel density in oropharyngeal carcinomas and relationship with survival time AB - Introduction : Among head and neck cancers, those of the oral cavity and oropharynx are the second most prevalent following the larynx. This study aimed to research immunohistochemical expression of survivin, HPV positivity and microvessel density in tumors and their relationships with prognosis. Material and methods: Pathological materials and demographic properties of 46 patients were retrospectively evaluated. Survivin, HPV and CD34 (for microvessel density evaluation) antibodies were applied tumoral tissues. Survival times, clinical stage and differentiation were evaluated. Results: In univariate analysis, we observed that survivin, microvessel density and stage were significantly associated with survival time (p < 0.05). In multivariate analysis, only survivin and microvessel density were associated with survival time (p 0.05). Conclusions : Survivin levels and microvessel density were found to be effective prognostic factors and were related to survival in oral cavity and oropharyngeal cancers. Treatments targeting survivin expression and angiogenesis might be employed against these tumor groups. AU - Tastekin, Ebru AU - Caloglu, Vuslat Yurut AU - Durankus, Nilufer Kilic AU - Sut, Necdet AU - Turkkan, Gorkem AU - Can, Nuray AU - Puyan, Fulya Oz AU - Caloglu, Murat SP - 1467 EP - 1473 DA - 2017 DO - 10.5114/aoms.2015.56616 UR - http://dx.doi.org/10.5114/aoms.2015.56616 ER -