TY - JOUR JO - Archives of Medical Science SN - 1734-1922 VL - 13 IS - 4 PY - 2017 ID - Ismail2017 TI - Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus AB - Introduction: Adiponectin, leptin and resistin are adipokines that play important roles in the regulation of lipid and carbohydrate metabolism in type 2 diabetes (T2DM). However, their influence in type 1 diabetes mellitus is still unknown. The aim of this study was to measure serum adiponectin, leptin and resistin levels and to investigate their relationships with vitamin D and other clinical and laboratory parameters in patients with type 1 diabetes. Material and methods : Fifty subjects with type 1 diabetes and 50 healthy age- and sex-matched subjects were selected from the Endocrinology Outpatient Clinic of Cairo University Pediatrics Hospital. Enzyme-linked immunosorbent assay was used to measure the levels of leptin, adiponectin and resistin. Vitamin D levels were measured using electro-chemiluminescence immunoassay. Results : There were no significant differences in adiponectin and leptin levels between diabetic and control subjects (p = 0.6 and p = 0.5 respectively). Resistin levels were significantly higher in the diabetic group compared to controls (p < 0.001) and in postpubertal patients compared to prepubertal patients (p < 0.04). Serum resistin in type 1 diabetes showed a negative correlation with vitamin D (p < 0.001) and a positive correlation with glycated hemoglobin (HbA 1c ) (p = 0.006), while other adipokines were not interrelated. Conclusions : These results strongly support a role of resistin and vitamin D deficiency in the pathophysiology of type 1 diabetes. Vitamin D may be involved in resistin regulation through an unknown mechanism. Further studies are recommended to understand resistin regulation in type 1 diabetes. AU - Ismail, Mohamed M. AU - Hamid, Tamer A. Abdel AU - Ibrahim, Alshaymaa AU - Marzouk, Huda SP - 738 EP - 744 DA - 2017 DO - 10.5114/aoms.2016.60680 UR - http://dx.doi.org/10.5114/aoms.2016.60680 ER -