TY - JOUR JO - Polish Journal of Pathology SN - 1233-9687 VL - 67 IS - 3 PY - 2016 ID - Miłek2016 TI - Mast cells influence neoangiogenesis in prostatic cancer independently of ERG status AB - A significant proportion of prostatic adenocarcinomas show recurrent translocation leading to ERG expression. Previously we found that ERG+ cases have higher microvessel density than negative ones. One factor influencing angiogenesis in cancer is mast cells. The aim of the present study was to evaluate the relationship between microvessels, mast cells and ERG status. Tissue microarrays prepared from 113 radical prostatectomy specimens were analyzed with immunohistochemistry for CD31, tryptase and chymase. Vascular profiles and tryptase-positive and chymase-positive cells were counted. The average number of tryptase-positive cells was 28.93/mm 2 and chymase-positive cells 9.91/mm 2 . The average number of CD31+ vascular profiles was 352.66/mm 2 . The average number of tryptase-positive cells was 26.35/mm 2 for ERG– cases and 32.12/mm 2 for ERG+ cases. The average number of chymase-positive cells was 8.14/mm 2 for ERG– cases and 12.06/mm 2 for ERG+ cases. The average number of CD31+ vascular profiles was 321.34/mm 2 for ERG– cases and 390.74/mm 2 for ERG+ cases. The number of CD31+ vascular profiles was positively correlated with the number of tryptase-positive and chymase-positive cells (R = 0.26 and R = 0.20). In summary, we demonstrated an interrelationship between mast cells, microvascular density and ERG status in prostatic carcinoma. AU - Miłek, Katarzyna AU - Kaczmarczyk-Sekuła, Karolina AU - Strzępek, Aleksandra AU - Dyduch, Grzegorz AU - Białas, Magdalena AU - Szpor, Joanna AU - Gołąbek, Tomasz AU - Szopiński, Tomasz AU - Chłosta, Piotr AU - Okoń, Krzysztof SP - 244 EP - 249 DA - 2016 DO - 10.5114/pjp.2016.62027 UR - http://dx.doi.org/10.5114/pjp.2016.62027 ER -