TY - JOUR JO - Menopause Review/Przegląd Menopauzalny SN - 1643-8876 VL - 3 IS - 6 PY - 2004 ID - Smolarz2004 TI - Microsatellite instability in breast carcinoma AB - Background: Microsatellite instability (MSI) is due to defective DNA mismatch repair. Defects in DNA mismatch-repair (MMR) genes lead to replication errors revealed as instability in microsatellite markers. Studies have shown that both hereditary breast cancer and sporadic breast cancer may be associated with mutations in a mismatch repair genes, such as MSH2, MLH1, PMS1, PMS2 and MSH6. Approach: Results from studies that assayed microsatellite instability in hereditary and sporadic breast cancer are reviewed. Conlusion: Several data suggest that microsatellite instability seem to be a risk factor both breast cancer in subjects belonged to HNPCC (Hereditary Nonpyloposis Colorectal Cancer) families with high incidence of this cancer and sporadic breast cancer. AU - Smolarz, Beata AU - Romanowicz-Makowska, Hanna AU - Kozłowska, Elżbieta AU - Zadrożny, Marek AU - Stetkiewicz, Tomasz AU - Pertyński, Tomasz AU - Kulig, Andrzej SP - 40 EP - 46 DA - 2004 UR - https://www.termedia.pl/Microsatellite-instability-in-breast-carcinoma,4,2826,1,1.html ER -