TY - JOUR JO - Central European Journal of Immunology SN - 1426-3912 VL - 42 IS - 1 PY - 2017 ID - Ma2017 TI - MicroRNA-20b promotes the accumulation of CD11b+Ly6G+Ly6Clow myeloid-derived suppressor cells in asthmatic mice AB - miR-20b is a member of the miR-106a-363 gene cluster, which has been shown to play an important role in a variety of diseases, including cancer, inflammation, and autoimmune diseases. Our previous study indicated that miR-20b has an inhibitory effect on airway inflammation in asthmatic mice, but the exact mechanism is unclear. In this study, we report that the ratio of CD11b+Ly6G+Ly6C low cells, but not the amount of CD11b+Ly6C+Ly6G– cells, was increased in the lung tissue of asthmatic mice after intranasal instillation with miR-20b mimics, while Th2-type cytokines (interleukin (IL)-4 and IL-13) were significantly decreased in the bronchoalveolar lavage fluid. In addition, the transcription factor CREB regulated the expression of miR-20b. Our findings suggest that miR-20b can induce the accumulation of myeloid-derived suppressor cells in the lungs of asthmatic mice, which may be a mechanism by which miR-20b inhibits airway inflammation in asthmatic mice. Thus, miR-20b may be used as a target for the effective treatment of asthma in the future. AU - Ma, Hua AU - Guo, Shujun AU - Luo, Yulan AU - Wang, Yimeng AU - Wang, Helong AU - He, Jing AU - Tang, Jie AU - Shen, Lin AU - Song, Chuanwang SP - 30 EP - 38 DA - 2017 DO - 10.5114/ceji.2017.67316 UR - http://dx.doi.org/10.5114/ceji.2017.67316 ER -