TY - JOUR JO - Polish Journal of Pathology SN - 1233-9687 VL - 69 IS - 1 PY - 2018 ID - Dziuba2018 TI - Rhabdomyosarcoma in children – current pathologic and molecular classification AB - The last 25 years have brought significant progress in the treatment of sarcomas in children, especially rhabdomyosarcoma (RMS). Nevertheless, treatment failure in some patients results from considerable biological heterogeneity noted in these tumours. RMS, the most common malignant soft tissue neoplasm in children, includes two main subtypes: embryonal (ERMS) and alveolar (ARMS). Due to greater aggressiveness and worse prognosis of ARMS in comparison to ERMS, discrimination between different rhabdomyosarcoma subtypes is of crucial clinical importance. This paper presents the current histological classification of RMS, up-to-date immunohistochemical and biological research regarding RMS, and its associated clinical and prognostic significance. AU - Dziuba, Ireneusz AU - Kurzawa, Paweł AU - Dopierała, Michał AU - Larque, Ana B. AU - Januszkiewicz-Lewandowska, Danuta SP - 20 EP - 32 DA - 2018 DO - 10.5114/pjp.2018.75333 UR - http://dx.doi.org/10.5114/pjp.2018.75333 ER -