TY - JOUR JO - Archives of Medical Science SN - 1734-1922 VL - 15 IS - 4 PY - 2019 ID - Fila2019 TI - Mitochondria in migraine pathophysiology – does epigenetics play a role? AB - The approximately three times higher rate of migraine prevalence in women than men may result from the mitochondrial transmission of this disease. Studies with imaging techniques suggest disturbances in mitochondrial metabolism in specific regions of the brain in migraine patients. Migraine shares some clinical features with several mitochondrial diseases and many other disorders include migraine headaches. Epigenetic regulation of mitochondrial DNA (mtDNA) is a matter of debate and there are some conflicting results, especially on mtDNA methylation. Micro RNAs (miRNAs) and long-noncoding RNA (lncRNAs) have been detected in mitochondria. The regulation of the miRNA-lncRNA axis can be important for mitochondrial physiology and its impairment can result in a disease phenotype. Further studies on the role of mitochondrial epigenetic modifications in migraine are needed, but they require new methods and approaches. AU - Fila, Michał AU - Pawłowska, Elżbieta AU - Blasiak, Janusz SP - 944 EP - 956 DA - 2019 DO - 10.5114/aoms.2019.86061 UR - http://dx.doi.org/10.5114/aoms.2019.86061 ER -