TY - JOUR JO - Central European Journal of Immunology SN - 1426-3912 VL - 44 IS - 2 PY - 2019 ID - Olewicz-Gawlik2019 TI - A case of bizarre posttransplant anti-glomerular basement membrane disease AB - The non-collagenous (NC1) domain of 3 and 5 chains of type IV collagen are eminent targets of abnormal immune response in anti-glomerular basement membrane (anti-GBM) disease, which can be diagnosed by the presence of strong linear IgG staining along GBM detected by direct immunofluorescence. The presence of linear GBM fixation in renal allograft is a rare finding. We observed a 33-year-old male with de novo renal failure in a kidney transplant. An examination of a kidney biopsy specimen revealed, in light microscopy, mild mesangial hypercellularity together with mild focal interstitial fibrosis and sparse inflammatory infiltrate. In immunofluorescence microscopy strong linear IgG staining along the capillary walls was seen. Serum anti-GBM antibodies were negative and no mutation in exons coding NC1 domains of 3 and 5 chains of type IV collagen were detected. We described a rare case of a patient with atypical anti-GBM disease in renal allograft, caused probably by the same process which affected the native kidneys. AU - Olewicz-Gawlik, Anna AU - Żeromski, Jan AU - Świerczewska, Monika AU - Idasiak-Piechocka, Ilona AU - Pawlik, Magdalena AU - Sikorska, Dorota AU - Samara, Husam AU - Oko, Andrzej AU - Sikora, Jan AU - Dworacki, Grzegorz SP - 210 EP - 213 DA - 2019 DO - 10.5114/ceji.2019.87074 UR - http://dx.doi.org/10.5114/ceji.2019.87074 ER -