TY - JOUR JO - Journal of Contemporary Brachytherapy SN - 1689-832X VL - 11 IS - 5 PY - 2019 ID - Suzuki2019 TI - Abscopal effect of high-dose-rate brachytherapy on pelvic bone metastases from renal cell carcinoma: a case report AB - Radiation therapy is considered an optimal partner for immunotherapies. Several pre-clinical studies have demonstrated that regression of distant metastases, at remote non-irradiated sites of the body, termed the “abscopal effect”, can be achieved by an appropriate timing and combination of radiation with immunotherapy. However, nearly all pre-clinical and clinical studies evaluating a combination of radiation and immunotherapies have used external beam radiation therapy. We present in this case report, the abscopal effect observed in a 30-year-old Japanese woman with metastatic renal cell carcinoma after the treatment with high-dose-rate interstitial brachytherapy combined with nivolumab. This is the first published report demonstrating an abscopal effect following brachytherapy for human malignancy. Our case indicates that immuno-oncology effects are not limited to external beam irradiation regimens as they can also be attained by brachytherapy. AU - Suzuki, Gen AU - Masui, Koji AU - Yamazaki, Hideya AU - Takenaka, Tadashi AU - Asai, Syunsuke AU - Taniguchi, Hidefumi AU - Nakamura, Terukazu AU - Ukimura, Osamu AU - Yamada, Kei SP - 458 EP - 461 DA - 2019 DO - 10.5114/jcb.2019.89365 UR - http://dx.doi.org/10.5114/jcb.2019.89365 ER -