TY - JOUR JO - Folia Neuropathologica SN - 1641-4640 VL - 57 IS - 4 PY - 2019 ID - Tang2019 TI - Epigallocatechin gallate enhances the motor neuron survival and functional recovery after brachial plexus root avulsion by regulating FIG4 AB - The survival of motor neurons (MNs) is the key to recovery of the motor function after brachial plexus root avulsion (BPRA). (-)-epigallocatechin-3-gallate (EGCG) exerts neuroprotective roles in neurons under different pathological conditions. However, the role of EGCG in regulating motor neurons under BPRA remains to be unclear. In the present study, we investigated the functional role of EGCG both in vitro and in vivo . In an in vitro study, we observed that EGCG obviously increased the cell survival rate of MNs and FIG4 protein levels compared with the vehicle control, with a peak level observed at 50 µM; EGCG can also upregulate FIG4 to reduce the cell death of MNs and increase the neurite outgrowth under oxidative stress; moreover, EGCG can upregulate FIG4 to promote the functional recovery and the survival of MNs in the ventral horn in mice after BPRA. These combined results may lay the foundation for EGCG to be a novel strategy for the treatment of BPRA. AU - Tang, Yinjuan AU - Wang, Jianjun AU - Wan, Shengjie AU - Luo, Lanbing AU - Qiu, Yuxia AU - Jiang, Shiyin AU - Yue, Guihua AU - Tang, Yumei AU - Tang, Weijun SP - 340 EP - 347 DA - 2019 DO - 10.5114/fn.2019.90819 UR - http://dx.doi.org/10.5114/fn.2019.90819 ER -