TY - JOUR JO - Reumatologia/Rheumatology SN - 0034-6233 VL - 58 IS - 5 PY - 2020 ID - Skoczyńska2020 TI - Pathophysiology of hyperuricemia and its clinical significance – a narrative review AB - Hyperuricemia, i.e. increased serum uric acid (UA) concentration, is a common problem in clinical practice. While there are clear guidelines concerning management of symptomatic hyperuricemia in acute conditions such as gout, urolithiasis or acute urate nephropathy, less is known about their secondary prevention. Moreover, despite the ongoing debate on the role of UA in the pathogenesis of chronic kidney disease, hypertension, cardiovascular disease and heart failure, the management of asymptomatic hyperuricemia in patients with these chronic conditions is still mainly up to physicians’ judgement. Individual considerations should always be taken into account when prescribing urate-lowering therapy. In this narrative review study, we attempt to present current trends concerning treatment of patients with either symptomatic or asymptomatic hyperuricemia in the light of the available knowledge on the role of hyperuricemia in the development of gout, renal, cardiovascular and other diseases. AU - Skoczyńska, Marta AU - Chowaniec, Małgorzata AU - Szymczak, Anna AU - Langner-Hetmańczuk, Anna AU - Maciążek-Chyra, Beata AU - Wiland, Piotr SP - 312 EP - 323 DA - 2020 DO - 10.5114/reum.2020.100140 UR - http://dx.doi.org/10.5114/reum.2020.100140 ER -